Characterization of differentially expressed plasma proteins in sufferers with acute

konka-chemica

Prediction of Radioresistant Prostate Most cancers Based mostly on Differentially Expressed Proteins

Introduction: 

Though relapses after radiotherapy are widespread in prostate most cancers (PCA) sufferers, these with a excessive threat for radioresistance can’t be recognized previous to therapy but. Subsequently, this proof-of-concept research was carried out to check protein expression profiles of sufferers with radio-recurrent PCA to sufferers handled with major radical prostatectomy separated by Gleason threat teams. We hypothesized that radio-recurrent PCA have an analogous protein expression as high-risk Gleason PCA.

Strategies:

Affected person cohorts consisted of (i) 31 sufferers handled with salvage prostatectomy for regionally recurrent PCA after major radiotherapy and (ii) 94 sufferers handled with major prostatectomy break up right into a Gleason high-risk (≥4 + 3; n = 42 [44.7%]) versus a low-risk group (≤3 + 4; n = 52 [55.3%]). Immunohistochemistry was carried out utilizing 15 antibodies with identified affiliation to radioresistance in PCA in vitro. ELISA was used for validation of chosen markers in serum.

Outcomes: 

Androgen receptor (AR) was overexpressed in most radio-recurrent PCA (89.7%) and in most major high-risk Gleason PCA (87.8%; p = 0.851), whereas solely 67.3% of the low-risk group confirmed an expression (p = 0.017). Contemplating the best Gleason sample in major PCA, aldo-keto reductase household 1 member C3 (AKR1C3) was most equally expressed by sufferers with radio-recurrent PCA and sufferers with Gleason patterns Four and 5 (p = 0.827 and p = 0.893) in comparison with Gleason sample 3 (p = 0.20). These findings had been supported by ELISA.

Conclusion:

That is the primary research to judge protein markers with a purpose to predict radioresistance in PCA. Our outcomes level to AR and AKR1C3 as essentially the most promising markers which may assist stratify sufferers for radiotherapy.

konka-chemica
konka-chemica

Human CCL-14

hAP-0138A 100ug
EUR 250

Anti-Human CCL-11 Antibody

101-M161 100 µg
EUR 399
Description: CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig CCL11 to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse, and human CCL11 have been isolated. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. In addition, human CCL11 also shows high amino acid sequence identity to human MCP1, 2, and 3. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.

Anti-Human CCL-14 Antibody

101-M162 100 µg
EUR 399
Description: CCL14 is a chemokine that promotes chemotaxis of T cells, monocytes, and eosinophils. It occurs in two isoforms resulting from differential mRNA splicing. Following cleavage of a 19 amino acid signal peptide, mature CCL14a (aa 20-93) is a 74 amino acid peptide that is also known as HCC1 (Hemofiltrate CC Chemokine1). It is a weak CCR1 agonist, however, an 8 amino acid Nterminal truncation (aa 28 93) allows potent signaling through CCR1 and CCR5. CCL14b, also called HCC3, is a 90 amino acid peptide (aa 20-109) resulting from the insertion of 16 amino acids between residues 7 and 8 of CCL14a.

Anti-Human CCL-28 Antibody

101-M185 100 µg
EUR 399
Description: CCL-28 or MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Anti-Human CCL-14 Antibody

101-M246 100 µg
EUR 399
Description: CCL14 is a chemokine that promotes chemotaxis of T cells, monocytes, and eosinophils. It occurs in two isoforms resulting from differential mRNA splicing. Following cleavage of a 19 amino acid signal peptide, mature CCL14a (aa 20-93) is a 74 amino acid peptide that is also known as HCC1 (Hemofiltrate CC Chemokine1). It is a weak CCR1 agonist, however, an 8 amino acid Nterminal truncation (aa 28 93) allows potent signaling through CCR1 and CCR5. CCL14b, also called HCC3, is a 90 amino acid peptide (aa 20-109) resulting from the insertion of 16 amino acids between residues 7 and 8 of CCL14a.

Anti-Human CCL-11 Antibody

101-M256 100 µg
EUR 399
Description: CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig CCL11 to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse, and human CCL11 have been isolated. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. In addition, human CCL11 also shows high amino acid sequence identity to human MCP1, 2, and 3. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.

Anti-Human CCL-13 Antibody

101-M257 100 µg
EUR 399
Description: CCL13, also known as Monocyte Chemoattractant Protein4 (MCP4), is a CC chemokine that acts as a chemoattractant for monocytes, eosinophils and T cells and as an activator of basophils. Human CCL13 cDNA encodes a 98 amino acid residue precursor protein with a 23 amino acid residue hydrophobic signal peptide that is cleaved to yield an 8 kDa, 75 aa mature CCL13. Mature CCL13 lacks any potential N-glycosylation sites and shares a pyroglutamate proline motif with other human MCP proteins. Human CCL13 is most homologous to MCP1, 3 and Eotaxin, exhibiting approximately 65-66% amino acid sequence identity. CCL13 mRNA is expressed by a number of activated cell types, including endothelial cells, macrophages, bronchial epithelium and type II alveolar cells, and perhaps lymphocytes. The bioactivities of CCL13 are mediated by the CC chemokine receptors CCR2 and CCR3.

Anti-Human CCL-16 Antibody

101-M259 100 µg
EUR 399
Description: CCL16, also known as HCC-4, is a CC chemokine that interacts with CCR1, CCR2, and CCR5. CCL16 is expressed weakly by NK cells, γδ T cells, and some T cells and is upregulated in monocytes by IL-10. CCL16 functions as a chemoattractant for monocytes and promotes the maturation of monocyte derived dendritic cells.

Anti-Human CCL-17 Antibody

101-M260 100 µg
EUR 399
Description: CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

Anti-Human CCL-18 Antibody

101-M261 100 µg
EUR 399
Description: CCL18, also known as PARC (Pulmonary and Activation-regulated Chemokine), is expressed by monocyte-derived dendritic cells and Th2 cytokine-stimulated macrophages. It functions as a chemoattractant for naïve T cells but not monocytes or neutrophils.

Anti-Human CCL-19 Antibody

101-M262 100 µg
EUR 399
Description: CCL19, also known as MIP3β and ELC (EBI1Ligand Chemokine), is a 77 amino acid (aa) β chemokine that is distantly related to other β chemokines (20-30% aa sequence identity). The gene for MIP3β has been mapped to chromosome 9p13 rather than chromosome 17 where the genes for many human β chemokines are clustered. MIP3β is constitutively expressed in various lymphoid tissues (including thymus, lymph nodes, appendix and spleen). The expression of MIP3β is downregulated by the antiinflammatory cytokine IL10. Recombinant MIP3β is chemotactic for cultured human lymphocytes. MIP3β is a ligand for CCR7 (previously referred to as the EpsteinBarr virus-induced gene 1 (EBI1) orphan receptor), a chemokine receptor that is expressed in various lymphoid tissues and activated B and T lymphocytes. CCR7 is strongly upregulated in B cells infected with EpsteinBarr virus and T cells infected with herpesvirus 6 or 7.

Anti-Human CCL-20 Antibody

101-M264 100 µg
EUR 399
Description: CCL20, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus, is one of many novel β chemokines identified through bioinformatics. CCL20 cDNA encodes a 96 amino acid (aa) residue precursor protein with a 26 aa residue signal peptide that is predicted to be cleaved to form the 70 aa residue mature secreted protein. CCL20 is distantly related to other β chemokines (20-28% aa sequence identity) and the gene for CCL20 has been mapped to chromosome 2 rather than 17. CCL20 has been shown to be expressed predominantly in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. The expression of CCL20 is strongly upregulated by inflammatory signals and downregulated by the anti-inflammatory cytokine IL10. Synthetic or recombinant CCL20 has been shown to be chemotactic for lymphocytes and to inhibit proliferation of myeloid progenitors in colony formation assays. CCL20 has now been shown to be a unique functional ligand for CCR6 (previously referred to as GPRCY4, CKRL3, or STRL22 orphan receptor), a chemokine receptor that is selectively and highly expressed in human dendritic cells derived from CD34+ cord blood precursors.

Anti-Human CCL-21 Antibody

101-M265 100 µg
EUR 399
Description: 6Ckine or CCL-21 is a novel CC chemokine discovered independently by three groups from the EST database. 6Ckine, also named SLC (Secondary Lymphoid-tissue Chemokine), CCL21 and Exodus2, shows 21 33% identity to other CC chemokines. 6Ckine contains the four conserved cysteines characteristic of β chemokines plus two additional cysteines in its unusually long carboxy-lterminal domain. Human 6Ckine cDNA encodes a 134 amino acid residue, highly basic, precursor protein with a 23 amino acid residue signal peptide that is cleaved to form the predicted 111 amino acid residue mature protein. Mouse 6Ckine cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity. 6Ckine is constitutively expressed at high levels in lymphoid tissues such as lymph nodes, spleen and appendix. In mouse, high levels of 6Ckine mRNA are also detected in the lung. The gene for human 6Ckine has been localized at human chromosome 9p13 rather than chromosome 17 where the genes of many human CC chemokines are clustered. The 6Ckine gene location is within a region of about 100 kb from the gene for MIP3β/ ELC, another novel CC chemokine.

Anti-Human CCL-22 Antibody

101-M266 100 µg
EUR 399
Description: CCL22, also named stimulated T cell chemotactic protein (STCP1) and MDC, is a CC chemokine initially isolated from clones of monocytederived macrophages. Human CCL22 cDNA encodes a precursor protein of 93 amino acid residues with a 24 amino acid residue predicted signal peptide that is cleaved to yield a 69 amino acid residue mature 8 kDa protein. At the amino acid sequence level, CCL22 shows less than 35% identity to other CC chemokine family members. Human CCL22 is expressed in dendritic cells, macrophages and activated monocytes. In addition, CCL22 expression is also detected in the tissues of thymus, lymph node and appendix. The gene for human CCL22 has been mapped to chromosome 16 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Recombinant or chemically synthesized mature CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL2 activated NK cells, and activated T lymphocytes. A CD8+ T lymphocytederived secreted soluble activity that suppresses infection by primary non-syncytium-inducing and syncytium-inducing HIV1 isolates and the T cell lineadapted isolate HIV1 IIIB, has been identified as CCL22. Based on aminoterminal sequence analysis, the major CD8 + T lymphocyte-derived CCL22 protein yielded an amino-terminal sequence of YGANM, which is two amino acid residues shorter than the predicted mature CCL22. The difference in potency between the two mature CCL22 isoforms has not been determined.

Anti-Human CCL-23 Antibody

101-M267 100 µg
EUR 399
Description: CCL23, also known as Myeloid Progenitor Inhibitory Factor1 (MPIF1), is a CC chemokine that is produced by some myeloid cell lines and monocytederived dendritic cells. It binds CCR1 and inhibits the differentiation of progenitor cells that give rise to granulocytes and macrophages. CCL23 is also chemotactic for resting T cells, neutrophils, monocytes and dendritic cells.

Anti-Human CCL-24 Antibody

101-M268 100 µg
EUR 399
Description: Eotaxin2, also named MPIF2 and Ckβ6, is a CC chemokine that is designated CCL24. Eotaxin2 cDNA encodes a 10.5 kDa, 119 amino acid residue precursor protein with a 26 aa residue signal peptide that is cleaved to generate a mature protein predicted to contain 93 amino acid residues with an N-glycosylation site. C-terminally truncated variants with 78, 73, 75 and 76 residues have also been described. Eotaxin 2 shares 40%, 42% and 39% amino acid sequence identity with other CC chemokines CCL7/MCP3, CCL3/MIP1α, and CCL11/Eotaxin, respectively. Eotaxin2 mRNA is weakly expressed in activated monocytes and T lymphocytes. Recombinant Eotaxin2 induces chemotaxis of eosinophils, basophils, and resting T lymphocytes, but not monocytes or activated T lymphocytes. Eotaxin2 also suppresses colony formation by high proliferative multipotential hematopoietic progenitors. On eosinophils, the effects of Eotaxin2, Eotaxin and CCL13/MCP4 are mediated by the receptor CCR3.

Anti-Human CCL-25 Antibody

101-M269 100 µg
EUR 399
Description: CCL25 (thymus-expressed chemokine) is a CC chemokine that is distantly related (approximately 20% amino acid sequence identity) to other CC chemokines. Human CCL25 cDNA encodes a 150 aa precursor protein with a 23 aa signal peptide that is cleaved to yield a 127 aa mature protein. Mouse CCL25 cDNA has also been cloned and shown to encode a 144 aa protein that exhibits 49% aa sequence identity to human CCL25. The expresssion of human and mouse CCL25 was shown to be highly restricted to the thymus and small intestine. Although dendritic cells have been demonstrated to be the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. The gene for mouse CCL25 has been mapped to chromosome 8 rather than chromosome 11 where many mouse CC chemokines are clustered. Recombinant human and mouse CCL25 are chemotactic for activated macrophages, dendritic cells and thymocytes. CCL25 is also a specific agonist for the CCR9 chemokine receptor.

Anti-Human CCL-26 Antibody

101-M270 100 µg
EUR 399
Description: Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Anti-Human CCL-27 Antibody

101-M271 100 µg
EUR 399
Description: CTACK or CCL-27 is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant human CTACK is a 10.2 kDa protein containing 88 amino acid residues.

Anti-Human CCL-28 Antibody

101-M272 100 µg
EUR 399
Description: CCL-28 or MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Anti-Human CCL-1 Antibody

101-M255 100 µg
EUR 399
Description: ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migra­tion routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.

Anti-Human CCL-2 Antibody

101-M263 100 µg
EUR 399
Description: CCL2 is a βchemokine that is also known as monocyte chemotactic protein 1 (MCP1). It is produced by a variety of cell types and is chemotactic for monocytes.

Anti-Human CCL-3 Antibody

101-M273 100 µg
EUR 399
Description: The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Anti-Human CCL-5 Antibody

101-M274 100 µg
EUR 399
Description: CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a member of the β (CC) chemokine subfamily. It binds and activates the chemokine receptors CCR1, 3 and 5.

Anti-Human CCL-7 Antibody

101-M275 100 µg
EUR 399
Description: MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP2 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58% amino acid identity with MCP2. CCL7 cDNA encodes a 99 amino acid residue precursor protein from which the N-terminal 23 amino acid residues are cleaved to generate the 76 amino acid residue mature CCL7. Mature CCL7 contains a potential N-linked and several possible O-linked glycosylation sites. Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.

Anti-Human CCL-8 Antibody

101-M276 100 µg
EUR 399
Description: CCL8, also known as Monocyte Chemoattractant Protein 2 (MCP2), is an inflammatory CC chemokine that attracts monocytes, eosinophils and basophils. It is produced by many cell types and signals through interactions with CCR1, CCR2, CCR3 and CCR5.

Anti-Human CCL-17 (TARC) Antibody

101-M164 100 µg
EUR 399
Description: CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

Anti-Human CCL-27 (CTACK) Antibody

101-M184 100 µg
EUR 399
Description: CTACK or CCL-27 is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant human CTACK is a 10.2 kDa protein containing 88 amino acid residues.

Mouse Monoclonal anti-Human CCL-11

hAP-0136 100ug
EUR 250

Mouse Monoclonal anti-Human CCL-11

hAP-0136A 100ug
EUR 250

Mouse Monoclonal anti-human CCL-28

hAP-0153 100ug
EUR 250

Mouse Monoclonal anti-human CCL-28

hAP-0153A 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-28

hAP-5717 50ug
EUR 400

Anti-Human CCL-5 (RANTES) Antibody

101-M191 100 µg
EUR 399
Description: CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a member of the β (CC) chemokine subfamily. It binds and activates the chemokine receptors CCR1, 3 and 5.

Mouse Monoclonal anti-Human CCL-1

hAP-0135 100ug
EUR 250

Anti-Mouse CCL-11 Antibody

103-M321 100 µg
EUR 399
Description: CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Mouse CCL11 cDNA encodes a 97 amino acid (aa) precursor protein from which the aminoterminal 23 aa are cleaved to generate the 74 aa mature mouse CCL11. At the protein sequence level, mature mouse CCL11 is approximately 60% identical to mature human and guinea pig CCL11. In addition, mouse CCL11 also shows high aa sequence identity to members of the MCP family. Mouse CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. CCL11 mRNA is expressed in a variety of tissues. The expression of CCL11 mRNA is induced in cultured endothelial cells in response to IFNγ. In addition, CCL11 mRNA is also induced in response to the transplantation of IL4secreting tumor cells. The CC chemokine receptor 3 (CCR3) has been identified as a specific human CCL11 receptor.

Anti-Mouse CCL-12 Antibody

103-M322 100 µg
EUR 399
Description: CCL12 is a cloned mouse CC chemokine most closely related to human MCP1 (66% amino acid (aa) sequence identity in the mature protein). Mouse CCL12 encodes a 104 aa residue precursor protein with a 22 aa residue predicted hydrophobic signal sequence that is cleaved to generate a 82 aa residue mature protein. CCL12 is expressed constitutively in the thymus and lymph nodes. Under inflammatory conditions, CCL12 expression is also induced in activated macrophages and mast cells. The gene for mouse MCP1 has been mapped to the CC chemokine cluster on chromosome 11. Recombinant CCL12 has been shown to be a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, CCL12 will also chemoattract eosinophils. CCL12 has been found to be a functional ligand for CCR2 but not CCR1, CCR3, or CCR5.

Anti-Mouse CCL-17 Antibody

103-M323 100 µg
EUR 399
Description: Human thymus and activationregulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse CCL17 was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse CCL17 cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse CCL17 is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant CCL17 has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, CCL17 was identified to be a specific functional ligand for CCR4 and CCR8, receptors that are selectively expressed on T cells.

Anti-Mouse CCL-19 Antibody

103-M324 100 µg
EUR 399
Description: CCL19/MIP3β, also known as ELC (EBI1Ligand Chemokine), is a β chemokine that binds specifically to the chemokine receptor CCR7/EBI1/ BLR2. Mouse (human) CCL19 cDNA encodes a 108 (98) amino acid precursor protein with a predicted 25 (21) aa signal peptide that is cleaved to form the 83 (77) aa mature secreted protein. CCL19 is distantly related to other β chemokines (20-30% aa sequence identity). Mouse CCL19 shares 83% aa sequence homology with human CCL19. CCL19 has been shown to be constitutively expressed in various lymphoid tissues (including thymus, lymph nodes, appendix, and spleen) in dendritic cells within the T-cell zone. The expression of CCL19 is downregulated by the antiinflammatory cytokine IL10. Recombinant CCL19 has been shown to be chemotactic for Tcells and Bcells. The CCL19 receptor (CCR7/ EBI1/ BLR2) is expressed in various lymphoid tissues and activated B and T lymphocytes. CCR7 is also strongly upregulated in Bcells infected with EpsteinBarr virus and T-cells infected with herpesvirus 6 or 7.

Anti-Mouse CCL-20 Antibody

103-M326 100 µg
EUR 399
Description: Macrophage inflammatory protein 3 alpha (MIP-3α) is a member of the CC chemokine superfamily and has been designated CCL20. CCL20 is a β chemokine that is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL-10. CCL20 binds to CCR6 to promote chemotaxis of lymphocytes and inhibit the proliferation of myeloid progenitors.

Anti-Mouse CCL-21 Antibody

103-M327 100 µg
EUR 399
Description: 6Ckine is a novel CC chemokine discovered independently by three groups from the EST database. 6Ckine, also named SLC (secondary lymphoidtissue chemokine), CCL21 and Exodus2, shows 21-33% identity to other CC chemokines. 6Ckine contains the four conserved cysteines characteristic of β chemokines plus two additional cysteines in its unusually long carboxy-lterminal domain. Human 6Ckine cDNA encodes a 134 amino acid highly basic precursor protein with a 23 amino acid residue signal peptide that is cleaved to form the predicted 111 amino acid residue mature protein. Mouse 6Ckine cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Human and mouse 6Ckine share 86% amino acid sequence identity. 6Ckine is constitutively expressed at high levels in lymphoid tissues such as lymph nodes, spleen and appendix. In mouse, high levels of 6Ckine mRNA are also detected in the lung. Unlike most CC chemokines, 6Ckine is not chemotactic for monocytes. Recombinant mouse 6Ckine is chemotactic in vitro for thymocytes and activated T cells. Recombinant human 6Ckine has been shown to be chemotactic for some human T cell lines, resting PBL, and cultured T cells expanded with PHA and IL2. 6Ckine has also been reported to inhibit hemopoietic progenitor colony formation in a dosedependent manner. 6Ckine acts via the CC receptor CCR7 on T cells and B cells.

Anti-Mouse CCL-22 Antibody

103-M328 100 µg
EUR 399
Description: CCL22, also known as ABCD1 and MDC (macrophage-derived chemokine), is a CC chemokine cloned from activated mouse B cells. Mouse CCL22 cDNA encodes a precursor protein of 92 amino acid (aa) residues with a 24 aa residue predicted signal peptide that is cleaved to yield a 68 aa residue mature 7.8 kDa protein. At the amino acid sequence level, mouse and human CCL22 share 64% identity and 83% similarity. The genomic organization of the mouse and human CCL22 genes are very similar, exhibiting sequence identity at the intron-exon boundaries. Mouse CCL22 is expressed at high levels in dendritic cells and activated B lymphocytes. Low levels of mouse CCL22 mRNA are also detectable in lung, unstimulated spleen cells, lymph node cells and in thymocytes. CCL22 is a functional ligand for the CC chemokine receptor 4. Recombinant or chemically synthesized mature mouse CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in activated mouse and human T cells.

Anti-Mouse CCL-24 Antibody

103-M329 100 µg
EUR 399
Description: Eotaxin2, also named myeloid progenitor inhibitory factor (MPIF2), is a member of the CC chemokine subfamily and is designated CCL24. Eotaxin2 is constitutively expressed in the jejunum and spleen. It can also be induced in the lung by allergen challenge and IL4. LPS and IL4 also differentially regulate the expression of Eotaxin2 in monocytes and macrophages. Mouse Eotaxin2 cDNA encodes a 119 amino acid (aa) precursor protein that shares approximately 58% aa sequence identity with human Eotaxin2. Functionally, Eotaxin2is most closely related to CCL11/Eotaxin and CCL26/Eotaxin3. The three proteins share low sequence homology but have been shown to be potent eosinophil chemoattractants that bind and activate the chemokine receptor CCR3, a receptor that is highly expressed in eosinophils. Eotaxin2 also has the ability to suppress myeloid cell proliferation, a biological function not shared by Eotaxin.

Anti-Mouse CCL-25 Antibody

103-M330 100 µg
EUR 399
Description: CCL25 (thymus expressed chemokine), also known as TECK (thymus-expressed chemokine), is a CC chemokine that is distantly related (twenty some % amino acid sequence identity) to other CC chemokines. Mouse CCL25 cDNA encodes a 144 amino acid residue precursor protein with a 23 amino acid residue signal peptide that is cleaved to yield a 121 residue mature protein. Mouse CCL25 shares 49% amino acid sequence identity with human CCL25. The expresssion of human and mouse CCL25 was shown to be highly restricted to the thymus and small intestine. Although dendritic cells have been demonstrated to be the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. The gene for mouse CCL25 has been mapped to chromosome 8.

Anti-Mouse CCL-27 Antibody

103-M331 100 µg
EUR 399
Description: CCL27, also known as CTACK (cutaneous T cel-lattracting chemokine), ALP, ILC, and ESkine, is a member of the CC family of chemokines. Mature mouse CCL27 is a 95 amino acid (aa) protein that shares 57% aa and 87% aa sequence identity with human and rat CCL27, respectively. It shares 18-31% aa sequence identity with other mouse CC chemokines. An alternately spliced form of mouse CCL27, known as PESKY, is localized to the nucleus and promotes cellular migration. CCL27 is constitutively expressed by keratinocytes and is upregulated by inflammatory stimuli and in wounded skin. CCL27 binds the chemokine receptor CCR10, glycosaminoglycans in the extracellular matrix, sulfated tyrosine residues on PSGL1, and determinants on the surface of fibroblasts and endothelial cells. CCL27 cooperates with CCL17/TARC in inducing the migration of cutaneous lymphocyte antigen (CLA) positive memory T cells to the skin during inflammation. Endothelial cellbound CCL27 can mediate the adhesion of those cells to CLA+ T cells. CCL27 also induces the migration of keratinocyte precursors from bone marrow to the skin, thereby promoting wound healing. In humans, serum CCL27 levels are elevated and correlate with disease severity in atopic dermatitis, psoriasis vulgaris, and mycosis fungoides.

Anti-Mouse CCL-28 Antibody

103-M332 100 µg
EUR 399
Description: Mouse CCL28 (CC chemokine ligand 28) is a novel CC chemokine cloned from a Rag1 mouse kidney cDNA library. Mouse CCL28 cDNA encodes a 130 amino acid (aa) precursor protein with a 22 aa signal peptide and a 108 aa mature protein. Mature human and mouse CCL28 share 83% aa identity. Among CC chemokines, CCL28 shares the most homology with CCL27/CTACK. Mouse CCL28 is produced by epithelial cells. Based on Northern blot analysis, it is mainly expressed in testes, kidney and brain. The receptor for CCL28 has been identified as the CCR10, which is also the receptor for CCL27/CTACK.

Anti-Mouse CCL-1 Antibody

103-M320 100 µg
EUR 399
Description: Mouse CCL1, also known as TCA3, is a member of the CC beta family of chemokines. The human chemokine I309, which shares approximately 42% amino acid (aa) sequence identity, has been assumed to be the homologue of mouse TCA3. Mouse TCA3 and human I309 also share significant sequence homology in the 5' flanking region of their genes and each contain an extra pair of cysteine residues not found in most other chemokines. CCL1 cDNA encodes a 92 aa residue precursor protein with a predicted 23 aa signal peptide that is cleaved to produce a 69 aa mature protein. The sequence of CCL1 contains one potential Nlinked glycosylation site. Mouse CCL1 is found on the distal portion of mouse chromosome 11 in a cluster with MIP1α, MIP1β and JE. CCL1 acts by binding to the seven transmembrane spanning G-protein coupled receptor, CCR8. CCL1 has been shown to chemoattract T cells.

Anti-Mouse CCL-2 Antibody

103-M325 100 µg
EUR 399
Description: Mouse CCL2 is a member of the β (CC) subfamily of chemokines. The mouse CCL2 gene was initially identified as a plateletderived growth factorinducible gene in mouse fibroblasts. Mouse CCL2 cDNA encodes a 148 amino acid (aa) residue with a putative 23 aa signal peptide that is cleaved to generate the mature protein. Mouse CCL2 shares 82% amino acid sequence identity with rat CCL2. Mouse CCL2 also shares 55% amino acid sequence identity with human MCP1. Compared to human MCP1, mouse CCL2 has a 49 aa residue extension at the carboxyterminus. When a DNA sequence encoding the 125 aa residue of the mature CCL2 protein was expressed in E. coli at R&D Systems, the purified protein had the predicted N-terminus but a mass of 8525 Da. The truncation of most of the C terminal extension could be due either to purification artifact or to posttranslational modification. The truncated recombinant CCL2 has a potency similar to that of human MCP1 in the monocyte chemotaxis assay. Mouse CCL2 has full activity on human cells while human MCP1 has limited activity on mouse cells.

Anti-Mouse CCL-3 Antibody

103-M333 100 µg
EUR 399
Description: The macrophage inflammatory proteins 1α (or CCL3) and 1β, two closely related but distinct proteins, were originally co purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1α shares approximately 77% and 70% amino acid identity with human MIP1α and mouse MIP1β, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. In the same assays, MIP1β was reported to be much less active. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Anti-Mouse CCL-4 Antibody

103-M334 100 µg
EUR 399
Description: CCL4, also known as macrophage inflammatory protein 1 beta (MIP1β), is a 12 kDa β chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells (1, 2). CCL4 attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. A CCL4 deficiency in mice promotes the development of autoantibodies, possibly as a result of compromised regulatory T cell recruitment. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP1α. The first two N-terminal amino acids can be cleaved from human CCL4 by CD26/DPPIV. Both the full length and truncated forms exert biological activity through CCR5, and the truncated form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of Mtropic HIV1 which utilizes CCR5 as a coreceptor. Both forms of CCL4 block HIV1 infection of T cells by inducing the downregulation of CCR5. Mature mouse CCL4 shares 77% and 86% amino acid sequence identity with human and rat CCL4, respectively.

Anti-Mouse CCL-5 Antibody

103-M335 100 µg
EUR 399
Description: CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa βchemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. Human and mouse RANTES exhibit cross-species activity on human and mouse cells (4). Mature mouse CCL5 shares 100% amino acid (aa) sequence identity with rat CCL5 and 75-88% with canine, cotton rat, feline, and human CCL5. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M tropic) but not X4 (T tropic) strains of HIV. The two N-terminal residues of CCL5 can be removed by CD26/DPPIV, generating a protein that functions as a chemotaxis inhibitor and more effectively blocks M tropic HIV 1 infection of monocytes. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4. The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes. CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature.

Anti-Mouse CCL-6 Antibody

103-M336 100 µg
EUR 399
Description: Mouse CCL6, a member of the β subfamily of chemokines, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. Compared to other chemokines, mCCL6 has a large N-terminal extension. The expression of CCL6 mRNA has been detected in mouse monocytes and neutrophils, where it is strongly induced upon GM-CSF stimulation. CCL6 expression has also been detected in an IL2-dependent T cell line, where the expression is inhibited following T cell stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages. The gene for CCL6 has been mapped to mouse chromosome 11.

Anti-Mouse CCL-8 Antibody

103-M337 100 µg
EUR 399
Description: CCL8, also known as Monocyte Chemoattractant Protein 2 (MCP2), is an inflammatory CC chemokine that attracts monocytes, eosinophils and basophils. It is produced by many cell types and signals through interactions with CCR1, CCR2, CCR3 and CCR5.

Anti-Mouse CCL-9 Antibody

103-M338 100 µg
EUR 399
Description: Mouse CCL9/10 (also named MIP1γ and MRP2) is an 11 kDa, secreted, monomeric polypeptide that belongs to the β (or CC) intercrine family of chemokines. Based on its activity and amino acid (aa) sequence, it is further classified as a member of the NC6 or six cysteinecontaining CC subfamily of chemokines. This subfamily contains four Nterminally extended chemokines, two human (CCL15 and CCL23) and two mouse (CCL9 and CCL10). Within this subfamily, there are no humanto rodent interspecies orthologs. Mouse CCL9/10 is synthesized as a 122 aa precursor that contains a 21 aa signal sequence and a 101 aa mature region with six cysteines. As noted, the mature region has an expanded Nterminus relative to other CC family members, and it forms a third intrachain disulfide bond with its two extra cysteines. Mouse CCL9/10 is 75% aa identical to rat CCL9/10. Chemokines are known to undergo proteolytic processing to generate multiple isoforms. NC6 chemokines are usually only marginally active at fulllength, but are converted to highly active forms upon Nterminal truncation. Mature CCL9, in the presence of inflammatory fluids, is naturally truncated by 28, 29 or 30 aa at the Nterminus, generating a highly active, 8 kDa, 71 73 aa CCR1 ligand. In contrast, other CCR1 ligands, CCL3/MIP1α and CCL5/RANTES, lose their potency when proteolytically processed. CCL9/10 is constitutively secreted, and circulates as a fulllength molecule. Any onset of inflammation with subsequent enzyme release may act on local NC6 chemokines, generating early, potent leukocyte chemoattractants.

Anti-Human CCL-23 (MPIF-1) Antibody

101-M183 100 µg
EUR 399
Description: CCL23, also known as Myeloid Progenitor Inhibitory Factor1 (MPIF1), is a CC chemokine that is produced by some myeloid cell lines and monocytederived dendritic cells. It binds CCR1 and inhibits the differentiation of progenitor cells that give rise to granulocytes and macrophages. CCL23 is also chemotactic for resting T cells, neutrophils, monocytes and dendritic cells.

Human CCL-5 ELISA Kit

EHC0240 96Tests
EUR 625.2

Mouse Monoclonal anti-human CCL-22 (MDC)

hAP-0147 100ug
EUR 250

Mouse Monoclonal anti-human CCL-17 (TARC)

hAP-0141 100ug
EUR 250

Mouse Monoclonal anti-human CCL-17 (TARC)

hAP-0141A 100ug
EUR 250

Mouse Monoclonal anti-human CCL-18 (PARC)

hAP-0142 100ug
EUR 250

Mouse Monoclonal anti-human CCL-25 (TECK)

hAP-0150 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-17 (TARC)

hAP-5708 50ug
EUR 400

Sheep Polyclonal anti-Human CCL-18 (PARC)

hAP-5709 50ug
EUR 400

Sheep Polyclonal anti-Human CCL-25 (TECK)

hAP-5714 50ug
EUR 400

Mouse Monoclonal anti-human CCL-27 (CTACK)

hAP-0152 100ug
EUR 250

Mouse Monoclonal anti-human CCL-27 (CTACK)

hAP-0152A 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-27 (CTACK)

hAP-5716 50ug
EUR 400

Mouse Monoclonal anti-human CCL-21 (6Ckine)

hAP-0146 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-21 (6Ckine)

hAP-5711 50ug
EUR 400

Mouse Monoclonal anti-human CCL-24 (Eotaxin)

hAP-0149 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-11 (Eotaxin)

hAP-5703 50ug
EUR 400

Sheep Polyclonal anti-Human CCL-24 (Eotaxin)

hAP-5713 50ug
EUR 400

Anti-Human CCL-3 (MIP1 alpha) Antibody

101-M186 100 µg
EUR 399
Description: The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Anti-Human CCL-3 (MIP1 alpha) Antibody

101-M187 100 µg
EUR 399
Description: The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Mouse Monoclonal anti-human CCL-5 (RANTES)

hAP-0155 100ug
EUR 250

Mouse Monoclonal anti-human CCL-5 (RANTES)

hAP-0155A 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-28

mAP-0179 100ug
EUR 250

Mouse Monoclonal anti-human CCL-13 (MCP-4)

hAP-0137 100ug
EUR 250

Mouse Monoclonal anti-human CCL-16 (HCC-4)

hAP-0140 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-13 (MCP-4)

hAP-5704 50ug
EUR 400

Sheep Polyclonal anti-Human CCL-16 (HCC-4)

hAP-5707 50ug
EUR 400

Mouse Monoclonal anti-human CCL-23 (MPIF-1)

hAP-0148 100ug
EUR 250

Mouse Monoclonal anti-human CCL-23 (MPIF-1)

hAP-0148A 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-14a (HCC-1)

hAP-5705 50ug
EUR 400

Sheep Polyclonal anti-Human CCL-23 (MPIF-1)

hAP-5712 50ug
EUR 400

Mouse Monoclonal anti-human CCL-26 (Eotaxin-3)

hAP-0151 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-26 (Eotaxin-3)

hAP-5715 50ug
EUR 400

Rat Monoclonal anti-mouse CCL-3

mAP-0180 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-4

mAP-0181 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-5

mAP-0182 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-6

mAP-0183 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-8

mAP-0184 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-9

mAP-0185 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-6

mAP-0340 100ug
EUR 250

Mouse Monoclonal anti-human CCL-2 (MCP-1)

hAP-0144 100ug
EUR 250

Mouse Monoclonal anti-human CCL-7 (MCP-3)

hAP-0156 100ug
EUR 250

Mouse Monoclonal anti-human CCL-8 (MCP-2)

hAP-0157 100ug
EUR 250

Sheep Polyclonal anti-human CCL-2 (MCP-1)

hAP-5073 50ug
EUR 400

Nori® Mouse CCL-15 (MIP-5) ELISA Kit

GR117261 96-well
EUR 461

Rat Monoclonal anti-mouse CCL-22 (MDC)

mAP-0175 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-17 (TARC)

mAP-0170 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-25 (TECK)

mAP-0177 100ug
EUR 250

Human MDC/CCL 22 ELISA KIT

E42EH-288 96T/48T Ask for price

Rat Monoclonal anti-mouse CCL-27 (CTACK)

mAP-0178 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-21 (6Ckine)

mAP-0174 100ug
EUR 250

Mouse Monoclonal anti-human CCL-19 (MIP-3 beta)

hAP-0143 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-19 (MIP-3 beta)

hAP-5710 50ug
EUR 400

Rat Monoclonal anti-mouse CCL-11 (Eotaxin)

mAP-0168 100ug
EUR 250

Mouse Monoclonal anti-human CCL-20 (MIP-3 alpha)

hAP-0145 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-20 (MIP-3 alpha)

hAP-5706 50ug
EUR 400

Mouse Monoclonal anti-human CCL-4 (MIP-1 beta)

hAP-1166 100ug
EUR 250

Mouse Monoclonal anti-human CCL-3 (MIP-1 alpha)

hAP-0154 100ug
EUR 250

Mouse Monoclonal anti-human CCL-3 (MIP-1 alpha)

hAP-0154A 100ug
EUR 250

Mouse Monoclonal anti-human CCL-3 (MIP-1 alpha)

hAP-0154B 100ug
EUR 250

Human RANTES (CCL 5) Recombinant Protein

100-095 20 µg
EUR 196.35
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Human RANTES (CCL 5) Recombinant Protein

100-095S 5 µg
EUR 92.4
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Rat Monoclonal anti-mouse CCL-12 (MCP-5)

mAP-0169 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-24 (Eotaxin-2

mAP-0176 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-1 (TCA-3)

mAP-0167 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-2 (MCP-1)

mAP-0172 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-19 (MIP-3 beta)

mAP-0171 100ug
EUR 250

Rat Monoclonal anti-mouse CCL-20 (MIP-3 alpha)

mAP-0173 100ug
EUR 250

Rat-MIP1γ CCL-9-

QY-E11948 96T
EUR 420

Human RANTES (CCL 5, Animal Free) Recombinant Protein

100-095-AF 20 µg
EUR 229.95
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Human RANTES (CCL 5, Animal Free) Recombinant Protein

100-095S-AF 5 µg
EUR 134.4
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Rat CCL-5 ELISA Kit

ERC0240 96Tests
EUR 625.2

Anti- Interleukin-15 (IL-15) Human -BIOTIN Antibody

GWB-66F8CF 0.025 mg Ask for price

Goat CCL-5 ELISA Kit

EGTC0240 96Tests
EUR 625.2

Mouse CCL-5 ELISA Kit

EMC0240 96Tests
EUR 625.2

Sheep CCL-5 ELISA Kit

ESC0240 96Tests
EUR 625.2

Monkey CCL-5 ELISA Kit

EMKC0240 96Tests
EUR 625.2

Rabbit CCL-5 ELISA Kit

ERTC0240 96Tests
EUR 625.2

Canine CCL-5 ELISA Kit

ECC0240 96Tests
EUR 625.2

Bovine CCL-5 ELISA Kit

EBC0240 96Tests
EUR 625.2

Porcine CCL-5 ELISA Kit

EPC0240 96Tests
EUR 625.2

Chicken CCL-5 ELISA Kit

ECKC0240 96Tests
EUR 625.2

Anserini CCL-5 ELISA Kit

EAC0240 96Tests
EUR 625.2

Eotaxin / CCL-11 (Mouse) - ELISA Kit

EK-033-40 96 wells
EUR 603.72

Guinea Pig CCL-5 ELISA Kit

EGC0240 96Tests
EUR 625.2

human anti-human IL-15 mAb(1A)

E4A09D21-1A 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-15 mAb(2B)

E4A09D21-2B 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-15 mAb(7C)

E4A09D21-7C 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-15 mAb(9E)

E4A09D21-9E 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human GDF-15 mAb (FD)

E4A09G02-hFD 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human GDF-15 mAb (FP)

E4A09G02-hFP 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human GDF-15 mAb (H2)

E4A09G02-hH2 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human GDF-15 mAb(32)

E4A09G02-h32 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human GDF-15 mAb(39)

E4A09G02-h39 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human GDF-15 mAb(82)

E4A09G02-h82 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat RANTES (CCL 5) Recombinant Protein

R20-012 20 µg
EUR 196.35
Description: RANTES is a protein which has been shown to be a chemoattractant for peripheral blood monocytes. It appears to selectively attract T cells of the CD4+/CD45RO+ phenotype in vitro. Recombinant Rat RANTES is a 7.9 kDa protein containing 68 amino acid residues.

Rat RANTES (CCL 5) Recombinant Protein

R20-012S 5 µg
EUR 92.4
Description: RANTES is a protein which has been shown to be a chemoattractant for peripheral blood monocytes. It appears to selectively attract T cells of the CD4+/CD45RO+ phenotype in vitro. Recombinant Rat RANTES is a 7.9 kDa protein containing 68 amino acid residues.

Cefpodoxime/ Clavulanic acid CCL 10/5

SD255-5CT 1 unit
EUR 7.89
Description: Cefpodoxime/ Clavulanic acid CCL 10/5

Cefpodoxime/ Clavulanic acid CCL 10/5

SD255-5VL 1 unit
EUR 14.2
Description: Cefpodoxime/ Clavulanic acid CCL 10/5

Mouse RANTES (CCL 5) Recombinant Protein

M10-038 20 µg
EUR 196.35
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant murine RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Mouse RANTES (CCL 5) Recombinant Protein

M10-038S 5 µg
EUR 92.4
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant murine RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Rabbit Anti Human Interleukin-15 Polyclonal Antibody

CPBT-65643RH 0.1 mg
EUR 1057.2

Immortalized PCK Cholangiocyte Cells (PCK CCL)

T0828 1x10^6 cells / 1.0 ml Ask for price

Anti-Human IL-15

GWB-BIG2AA 500ug Ask for price

Human Interleukin-15 (IL-15) Antibody

30145-05111 150 ug
EUR 215

Human Chemokine Ligand 15 (CCL15) ELISA Kit

IHUCCL15KT each
EUR 702
Description: Human Chemokine Ligand 15 (CCL15) ELISA Kit

Rabbit Anti Human OCLN Monoclonal Clone IEH-15

IRBAHUOCLNIEH15C100UL each
EUR 496
Description: Rabbit Anti Human OCLN Monoclonal Clone IEH-15

Rabbit Anti Human OGT Monoclonal Clone AEDG-15

IRBAHUOGTAEDG15C100UL each
EUR 496
Description: Rabbit Anti Human OGT Monoclonal Clone AEDG-15

Rabbit Anti Human OTX1 Monoclonal Clone BDH-15

IRBAHUOTX1BDH15C100UL each
EUR 496
Description: Rabbit Anti Human OTX1 Monoclonal Clone BDH-15

Rabbit Anti Human OLIG2 Monoclonal Clone ADC-15

IRBAHUOLIG2ADC15C100UL each
EUR 496
Description: Rabbit Anti Human OLIG2 Monoclonal Clone ADC-15

Rabbit Anti Human OPA1 Monoclonal Clone ACGD-15

IRBAHUOPA1ACGD15C100UL each
EUR 496
Description: Rabbit Anti Human OPA1 Monoclonal Clone ACGD-15

Rabbit Anti Human OPRD1 Monoclonal Clone GFC-15

IRBAHUOPRD1GFC15C100UL each
EUR 496
Description: Rabbit Anti Human OPRD1 Monoclonal Clone GFC-15

Rabbit Anti Human ORM2 Monoclonal Clone ACCC-15

IRBAHUORM2ACCC15C100UL each
EUR 496
Description: Rabbit Anti Human ORM2 Monoclonal Clone ACCC-15

Rabbit Anti Human OTX1 Monoclonal Clone ADBB-15

IRBAHUOTX1ADBB15C100UL each
EUR 496
Description: Rabbit Anti Human OTX1 Monoclonal Clone ADBB-15

Rabbit Anti Human OLFM4 Monoclonal Clone AFEB-15

IRBAHUOLFM4AFEB15C100UL each
EUR 496
Description: Rabbit Anti Human OLFM4 Monoclonal Clone AFEB-15

Nori® Ovine CCL-2/MCP-1 ELISA Kit

GR116154 96-well
EUR 461

Human CCL15/ C-C motif chemokine 15 ELISA Kit

E0373Hu 1 Kit
EUR 515
Description: MIP5,NCC3,SCYA15,Chemokine CC-2,Leukotactin-1,MIP-1 delta,Macrophage inflammatory protein 5,Mrp-2b,NCC-3,Small-inducible cytokine A15,HCC-2,LKN-1,MIP-5

Human CCL15(C-C motif chemokine 15) ELISA Kit

EH0058 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 11.719pg/ml

Human CCL15(C-C motif chemokine 15) ELISA Kit

E39EH0058 96T
EUR 595

Human CCL15/C-C motif chemokine 15 ELISA Kit

EK19260 96Т
EUR 553

Mouse Anti Human Papilloma virus type 18 (718-15)

MAB12255-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Human Papilloma Virus Type 18 (718-15)

Anti-Human IL-15 Antibody

102-P44 100 µg
EUR 245.7
Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues.

Anti-Human IL-15 Antibody

101-M480 100 µg
EUR 399
Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues.

Anti-Human MMP-15 Antibody

101-M117 100 µg
EUR 399
Description: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. They play critical roles in tissue remodeling, angiogenesis, tumor invasion, and rheumatoid arthritis. MMP15, also known as MT2MMP, is a membranetype MMP that is expressed in many tumor tissues including urothelial carcinoma, oral cancer, ovarian carcinoma, melanoma, and astrocytoma. Structurally, MMP15 consists of the following domains:a pro domain containing a furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexinlike domain, a transmembrane domain, and a cytoplasmic tail. Recombinant Human (rh) MMP15, consists of the pro domain, catalytic domain, hinge region and hemopexin-like domain. The pro domain contains the mutations R128P and R129G, which prevent activation by furin cleavage. Activation of rhMMP15 is possible by treatment with rhTrypsin.

Anti-Human GDF-15 Antibody

101-M432 100 µg
EUR 399
Description: GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.

Anti-Human GDF-15 Antibody

101-M755 100 µg
EUR 399
Description: GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.

Anti-Human MMP-15 Antibody

101-M807 100 µg
EUR 399
Description: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. They play critical roles in tissue remodeling, angiogenesis, tumor invasion, and rheumatoid arthritis. MMP15, also known as MT2MMP, is a membranetype MMP that is expressed in many tumor tissues including urothelial carcinoma, oral cancer, ovarian carcinoma, melanoma, and astrocytoma. Structurally, MMP15 consists of the following domains:a pro domain containing a furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexinlike domain, a transmembrane domain, and a cytoplasmic tail. Recombinant Human (rh) MMP15, consists of the pro domain, catalytic domain, hinge region and hemopexin-like domain. The pro domain contains the mutations R128P and R129G, which prevent activation by furin cleavage. Activation of rhMMP15 is possible by treatment with rhTrypsin.

Anti-Human ADAM-15 Antibody

101-M206 100 µg
EUR 399
Description: ADAM15 is a Metallopeptidase M12B type protease. ADAM metalloprotease-disintegrins mediate cell adhesion, proteolytic processing, and signal transduction. ADAM15 contains both protease and adhesion domains and may be involved in tumor invasion and metastasis.

Anti-Human GCDFP-15 antibody

STJ16100371 1 mL
EUR 1147.2

Nori® Porcine CCL-2/MCP-1 ELISA Kit

GR113217 96-well
EUR 461

The ribotoxin-like protein Ostreatin from Pleurotus ostreatus fruiting our bodies: Affirmation of a novel ribonuclease household expressed in basidiomycetes

Fungi produce a number of toxins energetic towards crops, animal or people. Amongst them, ribotoxins are enzymes that particularly assault ribosomes irreparably compromising protein synthesis, helpful as pesticides or as anticancer brokers. Right here, a novel ribotoxin from the edible mushroom Pleurotus ostreatus has been purified and characterised.

This ribotoxin, named Ostreatin, is a particular ribonuclease releasing α-fragment when incubated with yeast or rabbit ribosomes. Ostreatin exhibits IC50 of 234 pM in rabbit reticulocyte lysate, and metallic dependent endonuclease exercise. Following the completion of Ostreatin major construction, we ascertained that this toxin is homologous to Ageritin, the primary ribotoxin-like protein from the basidiomycete Agrocybe aegerita, with which it shares 38.8% amino acid sequence identification.

 Ostreatin consists of 131 amino acid residues with an experimental molecular mass of 14,263.51 Da ([M+H+]+). Homology modeling revealed that Ostreatin and Ageritin share an analogous fold by which the widespread catalytic triad is conserved.

Purified Ostreatin lacks N-terminal and C-terminal peptides, which as an alternative are current within the Ostreatin coding sequence. Such peptides are in all probability concerned in protein sorting and for this they might be eliminated. Our findings affirm the presence of ribotoxin-like proteins in basidiomycetes edible mushrooms, that we suggest as novel instrument for biotechnological functions.

Characterization of differentially expressed plasma  proteins in sufferers with acute myocardial infarction

Acute myocardial infarction (AMI) stays a number one reason for morbidity and mortality worldwide. Novel biomarkers are wanted to establish NSTEMI in AMI sufferers. The research goal was to make use of proteomics to establish novel plasma biomarkers for STEMI and NSTEMI sufferers. iTRAQ evaluation was carried out on pooled samples from Eight wholesome controls and 12 STEMI and 12 NSTEMI sufferers.

 Bioinformatics evaluation recognized 95 differentially expressed proteins that had been differentially expressed within the plasma of AMI sufferers and wholesome controls; 28 of those proteins had been present in STEMI/Con (22 upregulated and 6 downregulated), 48 in NSTEMI/Con (12 upregulated and 36 downregulated), and 44 in NSTEMI/STEMI (11 upregulated and 33 downregulated). Protein community evaluation was then carried out utilizing STRING software program.

Practical evaluation revealed that the recognized plasma proteins had been primarily concerned with carbon metabolism, toll-like receptor signaling pathway, and hypertrophic cardiomyopathy. 9 of the proteins (SSA1, MDH1, FCN2, GPI, S100A8, LBP, vinculin, VDBP, and RBP4) that modified ranges throughout AMI development had been additional validated by ELISA. The constructed plasma proteome may mirror the AMI pathogenesis molecular mechanisms and supply a technique for the early identification of NSTEMI in AMI sufferers. SIGNIFICANCE:

The goal of this research was to make use of proteomics to establish novel predictive plasma biomarkers for sufferers with acute myocardial infarction (AMI), which might enable for both identification of people liable to an infarction, and early identification of NSTEMI in sufferers with AMI. Utilizing an strategy that mixed iTRAQ with LC-MS/MS, we discovered 95 proteins that confirmed vital variations in expression ranges among the many AMI sufferers and wholesome controls.

The proteins SSA1, MDH1, FCN2, GPI, S100A8, LBP, vinculin, VDBP, and RBP4 had been discovered to play essential roles within the pathogenesis of AMI. Utilizing bioinformatics evaluation, we discovered that dysregulation of carbon metabolism, toll-like receptor signaling pathway, and hypertrophic cardiomyopathy would be the main driving forces for cardiac harm throughout myocardial infarction.

Nonetheless, additional investigations are wanted to confirm the mechanisms concerned within the improvement of AMI particularly NSTEMI. Taken collectively, our findings lay the muse for understanding the molecular mechanisms underlying the pathogenic processes of AMI, and recommend potential functions for particular biomarkers in early prognosis and willpower of prognosis.

2X Taq Master Mix, 100app

PLMM01 each Ask for price

2 × Rapid Taq Master Mix

P222-01 5 ml (5×1ml)
EUR 53.5

2 × Rapid Taq Master Mix

P222-02 15 ml (15×1ml)
EUR 144.5

2 × Rapid Taq Master Mix

P222-03 50 ml (50 x 1 ml)
EUR 430

2 × Rapid Taq Master Mix

P222-04 50 ml (10×5ml)
EUR 430

2x Taq PCR Master Mix

A4145-1ML40Rxns 1ML (40Rxns)
EUR 77
Description: Biotechnology

2 × Taq Plus Master Mix

P211-01 5 ml
EUR 58.81

2 × Taq Plus Master Mix

P211-02 15 ml
EUR 162.24

2 × Taq Plus Master Mix

P211-03 50 ml
EUR 507

2X ViRed Taq Master Mix, 100app

CLMM01 each Ask for price

2 × Taq Master Mix (Dye Plus)

P112-01 5 ml
EUR 36.91

2 × Taq Master Mix (Dye Plus)

P112-02 15 ml
EUR 98.42

2 × Taq Master Mix (Dye Plus)

P112-03 50 ml
EUR 290

2 × EpiArt HS Taq Master Mix

EM201-01 1ml
EUR 16

2 × EpiArt HS Taq Master Mix

EM201-02 5 ml (5×1ml)
EUR 70

4 × EpiArt HS Taq Master Mix

EM201-03 15 ml (15×1ml)
EUR 192

Apex 2X Taq Master Mix, Clear

42-133 100 Reactions/Unit
EUR 54.78
Description: 1.5mM MgCl2 (Final Conc.)

Apex 2X Taq Master Mix, Clear

42-134 500 Reactions/Unit
EUR 220.95
Description: 1.5mM MgCl2 (Final Conc.)

Apex 2X Taq Master Mix, Clear

42-134B 1000 Reactions/Unit
EUR 433.29
Description: 1.5mM MgCl2 (Final Conc.)

Apex Taq RED Master Mix, 2X

42-137 100 Reactions/Unit
EUR 58.5
Description: 1.5mM MgCl2 (Final Conc.)

Apex Taq RED Master Mix, 2X

42-138 500 Reactions/Unit
EUR 221.56
Description: 1.5mM MgCl2 (Final Conc.)

Apex Taq RED Master Mix, 2X

42-138B 1000 Reactions/Unit
EUR 437.28
Description: 1.5mM MgCl2 (Final Conc.)

ViPrimePLUS Taq qPCR Master Mix, 150rxns

QLMM11 each Ask for price

Taq PCR Master Mix (2X, Red Dye)

BS9297 1ml
EUR 101.76

Taq PCR Master Mix (2X, Red Dye)

BS9298 5ml
EUR 227.04

Taq PCR Master Mix (2X, Blue Dye)

BS9295 1ml
EUR 101.76

Taq PCR Master Mix (2X, Blue Dye)

BS9296 5ml
EUR 227.04

2X Taq PCR Master Mix (with dye)

K1034-1 1 ml
EUR 16

2X Taq PCR Master Mix (with dye)

K1034-100 100×1 ml
EUR 512

2X Taq PCR Master Mix (with dye)

K1034-20 20×1 ml
EUR 160

2X Taq PCR Master Mix (with dye)

K1034-5 5×1 ml
EUR 48

2X Taq PCR Master Mix (with dye)

K1034-50 50×1 ml
EUR 320

2 × Taq Plus Master Mix (Dye Plus)

P212-01 5 ml
EUR 159.6

2 × Taq Plus Master Mix (Dye Plus)

P212-02 15 ml
EUR 231.6

2 × Taq Plus Master Mix (Dye Plus)

P212-03 50 ml
EUR 466.8

3G Taq Master Mix for PAGE (Red Dye)

P115-01 5 ml
EUR 38.67

3G Taq Master Mix for PAGE (Red Dye)

P115-02 10 × 5 ml
EUR 290

2 × EpiArt HS Taq Master Mix (Dye Plus)

EM202-01 1ml
EUR 16

2 × EpiArt HS Taq Master Mix (Dye Plus)

EM202-02 5 ml (5×1ml)
EUR 70

2 × EpiArt HS Taq Master Mix (Dye Plus)

EM202-03 15 ml (15×1ml)
EUR 192

Taq Pro Universal SYBR qPCR Master Mix

Q712-02 500 rxns (20 μl/rxn)
EUR 161

Taq Pro Universal SYBR qPCR Master Mix

Q712-03 2,500 rxns (20 μl/rxn)
EUR 725

Accuris Taq Master Mix, 2X conc., 1000 reactions

PR1001-1000 1 PC
EUR 375.85

Accuris Taq Master Mix, 2X conc., 200 reactions

PR1001-200 1 PC
EUR 89.71

2 × Taq Plus Master Mix Ⅱ (Dye Plus)

P213-01 5 ml
EUR 58.81

2 × Taq Plus Master Mix Ⅱ (Dye Plus)

P213-02 15 ml
EUR 162.24

2 × Taq Plus Master Mix Ⅱ (Dye Plus)

P213-03 50 ml
EUR 507

Apex Hot Start Taq BLUE Master Mix, 2X

42-143 100 Reactions/Unit
EUR 65.77
Description: 1.5mM MgCl2 (Final)

Apex Hot Start Taq BLUE Master Mix, 2X

42-144 500 Reactions/Unit
EUR 288.71
Description: 1.5mM MgCl2 (Final)

Apex Hot Start Taq BLUE Master Mix, 2X

42-145 1000 Reactions/Unit
EUR 470.2
Description: 1.5mM MgCl2 (Final)

Apex Hot Start Taq BLUE Master Mix, 2X

42-146 2500 Reactions/Unit
EUR 1216.89
Description: 1.5mM MgCl2 (Final), Buffer I

Apex Hot Start Taq BLUE Master Mix, 2X

42-147 100 Reactions/Unit
EUR 61.77
Description: 1.5mM MgCl2 (Final), Buffer II

Apex Hot Start Taq BLUE Master Mix, 2X

42-148 500 Reactions/Unit
EUR 253.97
Description: 1.5mM MgCl2 (Final), Buffer II

Apex Hot Start Taq BLUE Master Mix, 2X

42-149 1000 Reactions/Unit
EUR 473.03
Description: 1.5mM MgCl2 (Final), Buffer II

Apex Hot Start Taq BLUE Master Mix, 2X

42-150 2500 Reactions/Unit
EUR 1072.65
Description: 1.5mM MgCl2 (Final), Buffer II

ViPrimePLUS Taq qPCR Green Master Mix I, 150rxns

QLMM12 each Ask for price

ViPrimePLUS Taq qPCR Green Master Mix II, 150rxns

QLMM17 each Ask for price

2X OneStep Taq ReverseTrans PCR Master Mix, 100apps

RTMM01 each Ask for price

ViPrimePLUS OneStep Taq RT-qPCR Master Mix, 150rxns

QLMM13 each Ask for price

Accuris Taq Master Mix, 2X conc., sample, 5 reactions

PR1001-S 1 PC
EUR 7.31

ViPrimePLUS Taq qPCR Master Mix with ROX, 150rxns

QLMM11-R each Ask for price

Geneaid Hot Start Taq PCR Master Mix with Dye

HSTQ004 each
EUR 2

Geneaid Hot Start Taq PCR Master Mix with Dye

HSTQ100 each
EUR 16.5

2X ViRed OneStep Taq ReverseTrans PCR Master Mix, 100apps

RTMM02 each Ask for price

Accuris Taq Master Mix Red Dye, 2X conc., 1000 reactions

PR1001-R-1000 1 PC
EUR 375.85

Accuris Taq Master Mix Red Dye, 2X conc., 200 reactions

PR1001-R-200 1 PC
EUR 90.95

Taqman Master Mix

M1121-500 each
EUR 529.2

Accuris Taq Plus Master Mix, 2X conc., 1000 reactions

PR1001-TP-1000 1 PC
EUR 1182.9

Accuris Taq Plus Master Mix, 2X conc., 200 reactions

PR1001-TP-200 1 PC
EUR 276.6

Accuris Hot Start Taq Master Mix, 2X conc., 1000 reactions

PR1001-HS-1000 1 PC
EUR 678.87

Accuris Hot Start Taq Master Mix, 2X conc., 200 reactions

PR1001-HS-200 1 PC
EUR 166.04

ViPrimePLUS Taq qPCR Master Mix with Low ROX, 150rxns

QLMM11-LR each Ask for price

ViPrimePLUS OneStep Taq RT-qPCR Green Master Mix I, 150rxns

QLMM14 each Ask for price

ViPrimePLUS OneStep Taq RT-qPCR Green Master Mix II, 150rxns

QLMM18 each Ask for price

Accuris Taq Master Mix Red Dye, 2X conc., sample, 5 reactions

PR1001-R-S 1 PC
EUR 7.31

Accuris Taq Plus Master Mix, 2X conc., sample, 20 reactions

PR1001-TP-S 1 PC
EUR 7.1

ViPrimePLUS Taq qPCR Green Master Mix I with ROX, 150rxns

QLMM12-R each Ask for price

ViPrimePLUS Taq qPCR Green Master Mix II with ROX, 150rxns

QLMM17-R each Ask for price

Taqman Master Mix-ROX

M1124-500 each
EUR 529.2

Accuris Hot Start Taq Master Mix Red Dye, 2X conc., 1000 reactions

PR1001-HSR-1000 1 PC
EUR 678.87

Accuris Hot Start Taq Master Mix Red Dye, 2X conc., 200 reactions

PR1001-HSR-200 1 PC
EUR 166.04

ViPrimePLUS OneStep Taq RT-qPCR Master Mix with ROX, 150rxns

QLMM13-R each Ask for price

Taqman Master Mix-iCycler

M1122-500 each
EUR 529.2

Taqman Master Mix-Multiplex

M1125-500 each
EUR 529.2

ViPrimePLUS Taq qPCR Green Master Mix I with Low ROX, 150rxns

QLMM12-LR each Ask for price

ViPrimePLUS Taq qPCR Green Master Mix II with Low ROX, 150rxns

QLMM17-LR each Ask for price

Ruby Taq Master (2x)

PCR-164L 20 x 1.25ml
EUR 466.7
Description: Ready-to-Use Mixes for PCR

Ruby Taq Master (2x)

PCR-164S 4 x 1,25ml
EUR 116.6
Description: Ready-to-Use Mixes for PCR

Ruby Taq Master (2x)

PCR-164XL 100ml
EUR 1492.9
Description: Ready-to-Use Mixes for PCR

Taqman Master Mix-Low ROX

M1123-500 each
EUR 529.2

Crystal Taq Master (2x)

PCR-166L 20 x 1.25ml
EUR 466.7
Description: Ready-to-Use Mixes for PCR

Crystal Taq Master (2x)

PCR-166S 4 x 1,25ml
EUR 116.6
Description: Ready-to-Use Mixes for PCR

Crystal Taq Master (2x)

PCR-166XL 100ml
EUR 1492.9
Description: Ready-to-Use Mixes for PCR

ViPrimePLUS OneStep Taq RT-qPCR Master Mix with Low Rox, 150rxns

QLMM13-LR each Ask for price

Accuris Hot Start Taq Master Mix Red Dye, 2X conc., sample, 5 reactions

PR1001-HSR-S 1 PC
EUR 7.31

Jade? Master Mix

M1105-500 each
EUR 529.2

qPCR Master Mix

abx460014-1096tests 10 × 96 tests Ask for price

qPCR Master Mix

abx460014-596tests 5 × 96 tests Ask for price

qPCR Master Mix

abx460014-96tests 96 tests
EUR 337.5

Red Load Taq Master (5x)

PCR-108L 5 x 1ml
EUR 207.1

Red Load Taq Master (5x)

PCR-108S 1ml
EUR 51.9

ViPrimePLUS OneStep Taq RT-qPCR Green Master Mix I with ROX, 150rxns

QLMM14-R each Ask for price

ViPrimePLUS OneStep Taq RT-qPCR Green Master Mix II with ROX, 150rxns

QLMM18-R each Ask for price

ViPrimePLUS OneStep Taq RT-qPCR Green Master Mix I with Low ROX, 150rxns

QLMM14-LR each Ask for price

ViPrimePLUS OneStep Taq RT-qPCR Green Master Mix II with Low ROX, 150rxns

QLMM18-LR each Ask for price

PCR Master Mix 2X

11140011-1 100 Reaction(s)
EUR 171.48

PCR Master Mix 2X

11140011-2 200 Reaction(s)
EUR 323.39

PCR Master Mix 2X

11140011-3 500 Reaction(s)
EUR 692.46

PCR Master mix (SYBR)

abx460031-1096tests 10 × 96 tests Ask for price

PCR Master mix (SYBR)

abx460031-596tests 5 × 96 tests Ask for price

PCR Master mix (SYBR)

abx460031-96tests 96 tests
EUR 337.5

2 × AceTaq Master Mix

P411-01 1 ml
EUR 142.8

2 × AceTaq Master Mix

P411-02 5 ml
EUR 189.6

2 × AceTaq Master Mix

P411-03 15 ml
EUR 314.4

AceQ Probe Master Mix

Q113-EN02 500 rxns (20 μl/rxn)
EUR 142.33

AceQ Probe Master Mix

Q113-EN03 2,500 rxns (20 μl/rxn)
EUR 634

amfiSure PCR Master Mix

P0311-010 2x50 rxns
EUR 151.2

amfiSure PCR Master Mix

P0311-025 5X50 rxns
EUR 198

amfiSure PCR Master Mix

P0311-050 10X50 rxns
EUR 262.8

amfiSure PCR Master Mix

P0311-100 10x1ml
EUR 343.2

amfiSure PCR Master Mix

P0311-125 15X50 rxns
EUR 333.6

amfiSure PCR Master Mix

P0311-200 20x1ml
EUR 562.8

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