
Structural Views on Extracellular Recognition and Conformational Modifications of A number of Sort-I Transmembrane Receptors
Sort-I transmembrane proteins characterize a big group of 1,412 proteins in people with a large number of capabilities in cells and tissues. They’re characterised by an extracellular, or luminal, N-terminus adopted by a single transmembrane helix and a cytosolic C-terminus.
The area composition and constructions of the extracellular and intercellular segments differ considerably amongst its members. Many of the type-I transmembrane proteins have roles in cell signaling processes, as ligands or receptors, and in mobile adhesion. The extracellular phase usually determines specificity and might management signaling and adhesion.
Right here we concentrate on latest structural understanding on how the extracellular segments of a number of various type-I transmembrane proteins have interaction in interactions and might bear conformational adjustments for his or her perform. Interactions on the extracellular aspect by proteins on the identical cell or between cells are enhanced by the transmembrane setting. Extracellular conformational area rearrangement and structural adjustments inside domains alter the properties of the proteins and are used to manage signaling occasions.
The mixture of structural properties and interactions can help the formation of larger-order assemblies on the membrane floor which are essential for mobile adhesion and intercellular signaling.

![]() Citrobacter rodentium RT PCR kit |
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RTq-V340-50D | Bioingentech | 50T | EUR 532.80 |
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Description: A Real-Time PCR kit for detection of Citrobacter rodentium . |
![]() Citrobacter rodentium One-Step PCR kit |
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Oneq-V340-100D | Bioingentech | 100T | EUR 747.40 |
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Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Citrobacter rodentium. |
![]() Citrobacter rodentium One-Step PCR kit |
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Oneq-V340-150D | Bioingentech | 150T | EUR 838.75 |
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Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Citrobacter rodentium. |
![]() Citrobacter rodentium One-Step PCR kit |
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Oneq-V340-50D | Bioingentech | 50T | EUR 628.50 |
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Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Citrobacter rodentium. |
MicroRNA-548ac induces apoptosis in laryngeal squamous cell carcinoma cells by focusing on transmembrane protein 158
Laryngeal most cancers is a standard head and neck most cancers that results the standard of lifetime of these affected. Early prognosis and therapy are important to attenuate the dangerous results of laryngeal most cancers, which may enhance the survival fee of sufferers following surgical procedure and retain the voice perform of the larynx.
The aim of the current examine was to discover the molecular mechanism of the event of laryngeal most cancers and to find out the biomarker for the prognosis and therapy of laryngeal most cancers. Reverse transcription-quantitative PCR (RT-qPCR) and The Most cancers Genome Atlas database evaluation had been used to verify excessive expression of TMEM158 in laryngeal most cancers.
The results of TMEM158 and miR-548ac was investigated by way of in vitro and in vivo assays (MTT assay, colony-formation assay, movement cytometry assay, western blotting and tumor xenograft assay). Luciferase reporter assay, western blotting and RTq-PCR had been used to verify that miR-548 instantly focused the three’-untranslated area of TMEM158 and inhibited TMEM158 expression.
Taken collectively, the current outcomes counsel that miR-548ac capabilities as a vital most cancers suppressor in laryngeal most cancers, which induces apoptosis in laryngeal most cancers cells by suppressing TMEM158. Thus, miR-548ac could also be a possible goal for the therapy of laryngeal most cancers.
S-palmitoylation of swine interferon-inducible transmembrane protein is crucial for its anti-JEV exercise
Japanese encephalitis virus (JEV) is an infectious pathogen spreading in a variety of vertebrate species. Pigs are amplifying hosts of JEV and considered maintained in nature predominantly by avian-mosquito cycles. Within the innate immune system,
interferon-inducible transmembrane protein (IFITM) is a small transmembrane protein household and has been recognized as the primary line of protection towards a broad vary of RNA virus invasion. On this paper, we discovered that swine IFITM (sIFITM) may prohibit the replication of each JEV vaccine pressure and wild pressure NJ-2008. The cysteine S-palmitoylation modification of sIFITM performs essential roles of their anti-JEV results and intracellular distributions.
Our findings present the anti-JEV actions of swine interferon-inducible transmembrane proteins and broaden the antiviral spectrum of IFITM protein household. The preliminary exploration of S-palmitoylation modification of sIFITM might contribute to understanding of the antiviral molecular mechanism of sIFITM.
Polymersome-based modular nanoreactors with size-selective transmembrane permeability.
Polymersome nanoreactors encapsulating the enzymes or particulate catalysts entice curiosity due to their potential use as modular reactors to synthesize complicated compounds through a cascade of chemical reactions in a single batch.
To realize these objectives, a key requirement is the tunable permeability of the polymersome membrane, which permits the size-selective transportation of reagents and merchandise whereas defending the encapsulated catalysts through the chemical response.
We report right here a stimuli-responsive route for controlling the permeability of the polymersomes of the binary mix of poly(ethylene glycol)-b-polystyrene (PEG-b-PS) and poly(ethylene glycol)-b-poly(acrylbenzylborate) (PEG-b-PABB). The presence of H2O2 (1 mM) within the medium (0.1M PBS, pH 7.4) triggers the oxidation of benzyl borate pendants of PABB to kind poly(acrylic acid) (PAA).
This transformation leads to the perforation of the compartmentalizing membrane of polymersomes by the dissolution of PEG-b-PAA domains embedded within the inert PEG-b-PS matrix. By controlling the composition of the stimuli-responsive block copolymer, the polymersomes of the binary mix exhibit size-selective permeability with out dropping the structural integrity. Launch of fluorescent company with completely different sizes (Fluorescein, PEG2k-Cm, PEG5k-Rho) will be managed by tuning the composition (PEG-b-PS/PEG-b-PABB = 100/0 ~ 80/20) of blended polymersomes.
Selective permeability of the membrane supplies safety of the encapsulated enzymes from exterior proteases current within the medium, ensuing within the one-pot synthesis of small molecules through cascades of chemical reactions.
The nanoparticular catalysts are additionally encapsulated throughout the permeable polymersomes, serving as modular reactors for the conversion of natural compounds through a cascade of reactions.
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abx022989-1ml | Abbexa | 1 ml | EUR 620.00 |
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PCR-H423-48D | Bioingentech | 50T | EUR 425.80 |
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Description: An conventional PCR kit for detection of Haemophilus influenzae |
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PCR-H423-96D | Bioingentech | 100T | EUR 521.50 |
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Description: An conventional PCR kit for detection of Haemophilus influenzae |
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DAG2703 | Creative Diagnostics | 1mg | EUR 1495.00 |
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RTq-H423-100D | Bioingentech | 100T | EUR 628.50 |
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Description: A Real-Time PCR kit for detection of Haemophilus influenzae . |
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RTq-H423-150D | Bioingentech | 150T | EUR 701.00 |
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Description: A Real-Time PCR kit for detection of Haemophilus influenzae . |
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RTq-H423-50D | Bioingentech | 50T | EUR 532.80 |
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Description: A Real-Time PCR kit for detection of Haemophilus influenzae . |
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Oneq-H423-100D | Bioingentech | 100T | EUR 747.40 |
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Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Haemophilus influenzae. |
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Oneq-H423-150D | Bioingentech | 150T | EUR 838.75 |
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Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Haemophilus influenzae. |
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Oneq-H423-50D | Bioingentech | 50T | EUR 628.50 |
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Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Haemophilus influenzae. |
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1-CSB-EP332793HSZ | Cusabio |
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Description: Recombinant Haemophilus influenzae Outer membrane protein P5(ompA) expressed in E.coli |
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1-CSB-EP669655HSZ | Cusabio |
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Description: Recombinant Haemophilus influenzae Outer membrane protein P2(ompP2) expressed in E.coli |
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ODN1668-B | Alpha Diagnostics | Custom | Ask for price |
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ODN1826-B | Alpha Diagnostics | Custom | Ask for price |
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VAng-Lsx03065-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Aerobic respiration control sensor protein ArcB homolog, recombinant protein. |
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VAng-Lsx03066-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4325.00 |
Description: Haemophilus Influenzae (strain PittGG) Ornithine carbamoyltransferase, recombinant protein. |
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VAng-Lsx03066-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3060.00 |
Description: Haemophilus Influenzae (strain PittGG) Ornithine carbamoyltransferase, recombinant protein. |
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VAng-Lsx03066-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2099.00 |
Description: Haemophilus Influenzae (strain PittGG) Ornithine carbamoyltransferase, recombinant protein. |
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VAng-Lsx03076-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4463.00 |
Description: Haemophilus Influenzae (strain PittEE) Chorismate synthase, recombinant protein. |
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VAng-Lsx03076-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3158.00 |
Description: Haemophilus Influenzae (strain PittEE) Chorismate synthase, recombinant protein. |
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VAng-Lsx03076-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2168.00 |
Description: Haemophilus Influenzae (strain PittEE) Chorismate synthase, recombinant protein. |
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VAng-Lsx03083-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3158.00 |
Description: Haemophilus Influenzae (strain 86-028NP) 3-dehydroquinate dehydratase, recombinant protein. |
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VAng-Lsx03083-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2250.00 |
Description: Haemophilus Influenzae (strain 86-028NP) 3-dehydroquinate dehydratase, recombinant protein. |
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VAng-Lsx03083-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1549.00 |
Description: Haemophilus Influenzae (strain 86-028NP) 3-dehydroquinate dehydratase, recombinant protein. |
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VAng-Lsx03084-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Arginine ABC transporter permease protein ArtM, recombinant protein. |
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VAng-Lsx03085-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Arginine ABC transporter permease protein ArtQ, recombinant protein. |
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VAng-Lsx03086-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 5164.00 |
Description: Haemophilus Influenzae (strain PittEE) Asparagine--tRNA ligase, recombinant protein. |
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VAng-Lsx03086-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3652.00 |
Description: Haemophilus Influenzae (strain PittEE) Asparagine--tRNA ligase, recombinant protein. |
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VAng-Lsx03086-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2484.00 |
Description: Haemophilus Influenzae (strain PittEE) Asparagine--tRNA ligase, recombinant protein. |
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VAng-Lsx03087-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain PittGG) ATP synthase subunit alpha, recombinant protein. |
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VAng-Lsx03090-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) ATP synthase subunit a, recombinant protein. |
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VAng-Lsx03097-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4037.00 |
Description: Haemophilus Influenzae (strain PittEE) ATP synthase gamma chain, recombinant protein. |
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VAng-Lsx03097-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2854.00 |
Description: Haemophilus Influenzae (strain PittEE) ATP synthase gamma chain, recombinant protein. |
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VAng-Lsx03097-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1961.00 |
Description: Haemophilus Influenzae (strain PittEE) ATP synthase gamma chain, recombinant protein. |
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VAng-Lsx03098-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3432.00 |
Description: Haemophilus Influenzae (strain PittGG) FMN-dependent NADH-azoreductase, recombinant protein. |
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VAng-Lsx03098-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2456.00 |
Description: Haemophilus Influenzae (strain PittGG) FMN-dependent NADH-azoreductase, recombinant protein. |
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VAng-Lsx03098-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1673.00 |
Description: Haemophilus Influenzae (strain PittGG) FMN-dependent NADH-azoreductase, recombinant protein. |
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VAng-Lsx03099-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3583.00 |
Description: Haemophilus Influenzae ATP-binding protein BexA, recombinant protein. |
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VAng-Lsx03099-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2553.00 |
Description: Haemophilus Influenzae ATP-binding protein BexA, recombinant protein. |
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VAng-Lsx03099-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1741.00 |
Description: Haemophilus Influenzae ATP-binding protein BexA, recombinant protein. |
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VAng-Lsx03100-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae Capsule polysaccharide export inner-membrane protein BexB, recombinant protein. |
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VAng-Lsx03101-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae Capsule polysaccharide export inner-membrane protein BexC (aa 1-377), recombinant protein. |
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VAng-Lsx03103-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4587.00 |
Description: Haemophilus Influenzae Capsule polysaccharide export protein BexD, recombinant protein. |
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VAng-Lsx03103-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3239.00 |
Description: Haemophilus Influenzae Capsule polysaccharide export protein BexD, recombinant protein. |
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VAng-Lsx03103-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2209.00 |
Description: Haemophilus Influenzae Capsule polysaccharide export protein BexD, recombinant protein. |
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VAng-Lsx03104-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4312.00 |
Description: Haemophilus Influenzae (strain PittGG) Biotin synthase, recombinant protein. |
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VAng-Lsx03104-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3048.00 |
Description: Haemophilus Influenzae (strain PittGG) Biotin synthase, recombinant protein. |
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VAng-Lsx03104-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2085.00 |
Description: Haemophilus Influenzae (strain PittGG) Biotin synthase, recombinant protein. |
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VAng-Lsx03105-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4312.00 |
Description: Haemophilus Influenzae (strain PittEE) Biotin synthase, recombinant protein. |
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VAng-Lsx03105-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3060.00 |
Description: Haemophilus Influenzae (strain PittEE) Biotin synthase, recombinant protein. |
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VAng-Lsx03105-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 2085.00 |
Description: Haemophilus Influenzae (strain PittEE) Biotin synthase, recombinant protein. |
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VAng-Lsx03109-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Heme exporter protein B, recombinant protein. |
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VAng-Lsx03110-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Heme exporter protein C, recombinant protein. |
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VAng-Lsx03111-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Heme exporter protein D, recombinant protein. |
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VAng-Lsx03114-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Phosphatidate cytidylyltransferase, recombinant protein. |
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VAng-Lsx03116-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 2895.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0133 protein CGSHiEE_00780, recombinant protein. |
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VAng-Lsx03116-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2071.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0133 protein CGSHiEE_00780, recombinant protein. |
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VAng-Lsx03116-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1439.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0133 protein CGSHiEE_00780, recombinant protein. |
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VAng-Lsx03117-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3762.00 |
Description: Haemophilus Influenzae (strain PittEE) Probable transcriptional regulatory protein CGSHiEE_01480, recombinant protein. |
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VAng-Lsx03117-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2690.00 |
Description: Haemophilus Influenzae (strain PittEE) Probable transcriptional regulatory protein CGSHiEE_01480, recombinant protein. |
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VAng-Lsx03117-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1824.00 |
Description: Haemophilus Influenzae (strain PittEE) Probable transcriptional regulatory protein CGSHiEE_01480, recombinant protein. |
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VAng-Lsx03118-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3390.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0301 protein CGSHiEE_01530, recombinant protein. |
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VAng-Lsx03118-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2415.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0301 protein CGSHiEE_01530, recombinant protein. |
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VAng-Lsx03118-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1659.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0301 protein CGSHiEE_01530, recombinant protein. |
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VAng-Lsx03119-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3225.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0225 protein CGSHiEE_01665, recombinant protein. |
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VAng-Lsx03119-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2305.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0225 protein CGSHiEE_01665, recombinant protein. |
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VAng-Lsx03119-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1576.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0225 protein CGSHiEE_01665, recombinant protein. |
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VAng-Lsx03120-inquire | Creative Biolabs | inquire | Ask for price |
Description: Haemophilus Influenzae (strain PittEE) UPF0761 membrane protein CGSHiEE_01670, recombinant protein. |
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VAng-Lsx03121-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 6044.00 |
Description: Haemophilus Influenzae (strain PittEE) Putative transport protein CGSHiEE_03135, recombinant protein. |
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VAng-Lsx03121-1mgYeast | Creative Biolabs | 1 mg (Yeast) | EUR 7295.00 |
Description: Haemophilus Influenzae (strain PittEE) Putative transport protein CGSHiEE_03135, recombinant protein. |
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VAng-Lsx03122-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 2785.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0250 protein CGSHiEE_03170, recombinant protein. |
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VAng-Lsx03122-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2003.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0250 protein CGSHiEE_03170, recombinant protein. |
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VAng-Lsx03122-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1384.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0250 protein CGSHiEE_03170, recombinant protein. |
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VAng-Lsx03123-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3762.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0271 protein CGSHiEE_03400, recombinant protein. |
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VAng-Lsx03123-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2690.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0271 protein CGSHiEE_03400, recombinant protein. |
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VAng-Lsx03123-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1824.00 |
Description: Haemophilus Influenzae (strain PittEE) UPF0271 protein CGSHiEE_03400, recombinant protein. |